BC Children's Hospital conducts research in a wide variety of areas.
- A large study (Canadian Childhood Asthma Primary Prevention Study) of over 500 families in Vancouver and Winnipeg has looked at how early developmental interventions might modify the expression of allergy and asthma in high-risk children. The study began in 1995, and showed a 56 per cent reduction in asthma development when the children were 7 years of age. Currently, the families are being re-assessed now that the children have reached their teenage years, with funding from the Canadian Institutes of Health Research (CIHR).
- In 2004 an epidemiologic study of the prevalence of asthma and allergic disease was undertaken in Vancouver of more than 3,000 children aged 12-14 years. This was part of the International Study of Asthma and Allergy in Children Phase 3. Participation of students was 95 per cent; almost double that of elsewhere in Canada.
- During the past several years, two large-scale randomized clinical trials have been conducted examining the safety of inhaled corticosteroids in children with asthma, and a third examined the efficacy and safety of adding long-acting beta-agonist therapy to regular inhaled corticosteroids in children.
Clinical care is changing all the time, based on research findings. Research in the Intensive Care Unit is broad based and members of the team are involved in basic research, single centre and multi centre clinical research and social and health care research.
Over the past several years, research has focused on studies of new drugs developed for the treatment of eczema and psoriasis. These are multi-centre clinical trials sponsored by the pharmaceutical industry.
Over the past two years, the Division of General Pediatrics has collaborated with other UBC divisions and Children’s departments to implement new clinical pathways and guidelines for asthma, urinary tract infections, laryngotracheobronchitis, and bronchiolitis. In each case, significant changes in health care to these populations have occurred as a result of implementation. Children are more effectively treated, improve more rapidly and require fewer hospital admissions.
Many members of the division have been involved in academic endeavours. Faculty have conducted and published research and delivered lectures on topics such as infant feeding and nutrition problems, pediatric pain, childhood asthma, chest pain, child maltreatment, recurrent pediatric abdominal pain and meningomyelocele.
The field of genetics is changing rapidly. This allows for the application of new developments to patient care and services each year. Our team of health care providers participate in numerous research studies which help to shed light onto the field of genetics and its relationship to patient care.
We provide every patient with the option of signing a consent form which allows us to contact you in the event of future research studies that may be applicable to your situation. Your genetic counsellor will be available to discuss any questions you may have about this.
The department generates research proposals, obtains funding and conducts specified research. Wherever possible, research will be done in conjunction with the University of British Columbia. Cross-appointed doctorate level pharmacists are involved in a variety of research projects, ranging from stability studies for pediatric formulations to drug effects in pregnancy.
The department provides support to other researchers and/or investigators involved in authorized hospital research activities in cooperation with the Research Institute.
The current focus of the activities includes:
non-invasive diagnostic and treatment techniques in pediatric heart disease
brain imaging in premature infants
seizure site mapping in the brain
bone tumour response to chemotherapy
magnetic resonance flow qualification
multislice computer tomography use in pediatrics
- Participation in a multi-centre Intensive Care Unit brain injury study
- Participation in and coordination of a multi-centre neonatal early nitric oxide intervention study
- Participation in a multi-centre neonatal caffeine trial
- Provincial Pulmonary Function equipment standardization study
- Department sponsored neonatal intubation and pain management study to assess the need for drug therapy and standardized clinical management
- Test centre for new technology (i.e. ventilators)
The Vaccine Evaluation Center (VEC) was established in 1988, making it the first formal center for independent vaccine research in Canada. The center is separate from government and vaccine manufacturers and provides independent, expert, consumer-oriented vaccine evaluations to help health authorities select the best vaccines and immunization programs
For more information or to take part in a VEC study, please see the VEC website.